Clinical SAS Programming Interview Questions and Answers

Clinical SAS Programming Interview Questions and Answers

Clinical SAS programming is a specialized field within SAS programming, focusing on the use of SAS software in clinical trials and healthcare data analysis. Below are some common Clinical SAS programming interview questions along with suggested answers to help you prepare for your interview.

1. What is Clinical SAS, and why is it important in clinical trials?

Answer: Clinical SAS refers to the use of SAS software in the analysis and reporting of clinical trial data. It is important because it enables the transformation of raw clinical data into meaningful insights that can be used for regulatory submissions, safety reporting, and decision-making in drug development. Clinical SAS ensures compliance with industry standards like CDISC and helps in generating accurate and reproducible results.

2. What are the CDISC standards, and why are they important in Clinical SAS programming?

Answer: CDISC (Clinical Data Interchange Standards Consortium) standards are a set of guidelines for organizing and formatting clinical trial data to ensure consistency and interoperability across studies. The two most common CDISC standards used in Clinical SAS are SDTM (Study Data Tabulation Model) and ADaM (Analysis Data Model). These standards are important because they facilitate data sharing, regulatory submissions, and efficient analysis.

3. What is the difference between SDTM and ADaM datasets?

Answer:

• SDTM (Study Data Tabulation Model): SDTM datasets are used to organize and standardize raw clinical trial data into predefined domains (e.g., DM for demographics, AE for adverse events). They represent the data as collected in the study.
• ADaM (Analysis Data Model): ADaM datasets are derived datasets created specifically for statistical analysis. They are designed to support the generation of statistical results and tables, and often include variables that are calculated or derived from the raw data.

4. Explain the importance of the `DEFINE.XML` file in clinical trials.

Answer: The `DEFINE.XML` file is a metadata document that accompanies SDTM and ADaM datasets during regulatory submissions to agencies like the FDA. It provides detailed information about the datasets, including variable definitions, controlled terminology, value-level metadata, and derivation methods. `DEFINE.XML` is crucial for ensuring that the submitted data is understood and interpreted correctly by reviewers.

5. How do you create an ADaM dataset from SDTM data in SAS?

Answer: Creating an ADaM dataset from SDTM data involves the following steps:

• Step 1: Identify the analysis requirements and the variables needed for analysis.
• Step 2: Extract relevant data from the SDTM datasets (e.g., DM, EX, LB).
• Step 3: Create derived variables based on analysis requirements (e.g., baseline values, change from baseline).
• Step 4: Merge data from different SDTM domains as needed to create the ADaM dataset.
• Step 5: Apply appropriate formats and labels, and ensure that the dataset meets ADaM standards.
• Step 6: Validate the ADaM dataset against the analysis requirements and ensure it is ready for statistical analysis.

6. What is the purpose of the `PROC TRANSPOSE` procedure in Clinical SAS programming?

Answer: `PROC TRANSPOSE` is used in Clinical SAS programming to pivot data from a wide format to a long format or vice versa. This is particularly useful when you need to convert repeated measures or multiple observations per subject into a single row per subject or when preparing data for specific analyses or reporting formats.

Example:

proc transpose data=wide_data out=long_data;
   by subject_id;
   var visit1 visit2 visit3;
   id visit;
run;

7. How do you handle missing data in clinical trials using SAS?

Answer: Handling missing data in clinical trials is critical to ensure the integrity and validity of the analysis. Common approaches include:

• Imputation: Replace missing values with estimated values based on the available data (e.g., last observation carried forward, mean imputation).
• Analysis using available data: Conduct the analysis using only the available data, ignoring the missing values (e.g., complete case analysis).
• Sensitivity analysis: Perform a sensitivity analysis to assess the impact of missing data on the study results.
• Documentation: Clearly document how missing data were handled in the statistical analysis plan and the final report.

8. Explain the use of `PROC REPORT` in clinical data reporting.

Answer: `PROC REPORT` is used in Clinical SAS programming to create customized tables and listings for clinical trial reports. It allows for flexible data presentation, including the ability to summarize data, apply formats, calculate statistics, and create complex table structures. `PROC REPORT` is often used to generate tables for clinical study reports (CSRs), including demographic summaries, adverse event listings, and efficacy tables.

Example:

proc report data=adam_ae nowd;
   column subject_id trtgrp ae_decod aebodsys aesev;
   define subject_id / group 'Subject ID';
   define trtgrp / group 'Treatment Group';
   define ae_decod / 'Adverse Event';
   define aebodsys / 'Body System';
   define aesev / 'Severity';
run;

9. How do you validate a SAS program in a clinical trial setting?

Answer: Validation of SAS programs in a clinical trial setting is essential to ensure the accuracy and reliability of the results. Common validation steps include:

• Independent Programming: Having another programmer independently write code to produce the same outputs and compare the results.
• Double Programming: Two programmers independently develop the same analysis or dataset, and their outputs are compared to identify discrepancies.
• Review of Log Files: Checking the SAS log for errors, warnings, and notes to ensure the program ran correctly.
• Peer Review: Having a peer review the code to ensure it follows best practices, is well-documented, and meets the study’s requirements.
• Test Data: Running the program on test datasets to check if it handles edge cases and missing data appropriately.

10. What is the role of `PROC LIFETEST` in clinical trials?

Answer: `PROC LIFETEST` is used in Clinical SAS programming to perform survival analysis, which is common in clinical trials with time-to-event endpoints (e.g., overall survival, progression-free survival). It provides estimates of survival functions using methods like the Kaplan-Meier estimator and can compare survival curves between treatment groups using log-rank tests.

Example:

proc lifetest data=adam_tte plots=survival;
   time time_to_event*censor(0);
   strata treatment_group;
   survival out=surv_curve;
run;

11. How would you generate a safety summary report in SAS?

Answer: To generate a safety summary report in SAS, you typically need to summarize adverse events, laboratory results, vital signs, and other safety data by treatment group. The steps involved include:

• Creating summary tables for adverse events, including counts and percentages of subjects with specific events.
• Summarizing laboratory data by treatment group, including means, medians, and changes from baseline.
• Generating listings of serious adverse events (SAEs) and other safety-related endpoints.
• Using `PROC REPORT` or `PROC TABULATE` to create the tables and ensuring the output meets the format and content requirements of the clinical study report (CSR).

12. What is the importance of traceability in ADaM datasets?

Answer: Traceability in ADaM datasets refers to the ability to trace the derivation of each variable back to its source in the SDTM datasets or raw data. This is important because it ensures that the data used in the analysis can be verified and understood by reviewers, which is crucial for regulatory compliance and the integrity of the study results.

13. How do you handle adverse event data in Clinical SAS programming?

Answer: Handling adverse event (AE) data in Clinical SAS programming involves several key steps:

• Standardizing AE terms using a medical dictionary like MedDRA (Medical Dictionary for Regulatory Activities).
• Categorizing AEs by severity, seriousness, and relationship to the study drug.
• Summarizing AEs by treatment group, body system, and preferred term.
• Creating tables and listings of AEs, including frequency counts and percentages.
• Ensuring that the AE data is consistent with the study protocol and analysis plan.

14. What is the role of the `PROC GLM` procedure in clinical trials?

Answer: `PROC GLM` (General Linear Model) is used in Clinical SAS programming to analyze data with multiple continuous and categorical independent variables. It is often used in clinical trials to compare treatment effects while adjusting for covariates, such as baseline characteristics or other prognostic factors.

Example:

proc glm data=adam_eff;
   class treatment_group;
   model change_from_baseline = treatment_group baseline_value;
   means treatment_group / hovtest=levene;
   run;
quit;

15. Explain the concept of Last Observation Carried Forward (LOCF) and how it is implemented in SAS.

Answer: Last Observation Carried Forward (LOCF) is a method for imputing missing data in longitudinal studies by carrying forward the last observed value of a variable to replace subsequent missing values. It is commonly used in clinical trials to handle dropout or missing follow-up data.

Example of LOCF implementation in SAS:

data locf;
   set adam_data;
   by subject_id visit;
   retain last_value;
   if not missing(value) then last_value = value;
   else value = last_value;
run;

16. How do you ensure data quality and integrity in clinical trial datasets?

Answer: Ensuring data quality and integrity in clinical trial datasets involves several practices:

• Data Cleaning: Identify and correct errors or inconsistencies in the data (e.g., out-of-range values, missing data).
• Data Validation: Use validation checks to ensure the data meets predefined standards and is consistent across datasets.
• Traceability: Ensure that each derived variable in ADaM datasets can be traced back to its source in SDTM or raw data.
• Version Control: Maintain version control of datasets and programs to track changes and ensure reproducibility.
• Documentation: Document all data handling and processing steps, including assumptions and decisions made during analysis.

17. What is the purpose of `PROC SQL` in Clinical SAS programming?

Answer: `PROC SQL` is used in Clinical SAS programming for data manipulation, querying, and summarization tasks. It allows for complex data joins, filtering, and summarization in a single step, making it a powerful tool for creating analysis datasets and generating reports.

Example:

proc sql;
   create table summary as
   select subject_id, treatment_group, count(ae_decod) as ae_count
   from adam_ae
   group by subject_id, treatment_group;
quit;

18. How do you create a clinical trial data listing in SAS?

Answer: Creating a clinical trial data listing in SAS involves the following steps:

• Selecting the relevant data (e.g., adverse events, laboratory results) and organizing it by subject, visit, or other key variables.
• Using procedures like `PROC PRINT`, `PROC REPORT`, or `PROC SQL` to format the data into a clear and readable table.
• Applying appropriate formats, labels, and titles to ensure the listing meets the study's requirements.
• Outputting the listing to the desired format (e.g., RTF, PDF) using ODS.

Example using `PROC PRINT`:

proc print data=adam_lab noobs;
   var subject_id visit lab_test result flag;
   title "Laboratory Results Listing";
run;

19. What is the difference between efficacy and safety analysis in clinical trials?

Answer:

• Efficacy Analysis: Focuses on assessing whether the treatment is effective in achieving the desired therapeutic effect. It typically involves analyzing primary and secondary endpoints related to the treatment's effectiveness.
• Safety Analysis: Focuses on assessing the safety and tolerability of the treatment. It involves analyzing adverse events, laboratory results, vital signs, and other safety-related endpoints.

20. How do you document your SAS programs in a clinical trial?

Answer: Documentation of SAS programs in a clinical trial is crucial for ensuring reproducibility, clarity, and regulatory compliance. Key aspects of documentation include:

• Header Section: Include the program name, author, date, purpose, and version history at the beginning of the program.
• Inline Comments: Add comments throughout the code to explain the logic, particularly for complex or non-obvious sections.
• Macro Documentation: Document macro variables and macro logic to explain their purpose and usage.
• Log File Review: Review and document any warnings, errors, or important notes from the SAS log.
• Final Output: Document the final output, including the datasets, tables, and listings generated by the program.

21. How do you handle adverse events with multiple occurrences for the same subject in clinical SAS programming?

Answer: Handling adverse events (AEs) with multiple occurrences for the same subject requires summarizing AEs and ensuring they are categorized correctly. Common approaches include:

• Summarizing the most severe AE for each subject by severity or seriousness.
• Counting the total number of unique AEs or the total number of AE occurrences per subject.
• Creating a flag for serious adverse events (SAEs) to differentiate them from other AEs.
• Using `PROC SQL`, `PROC FREQ`, or `PROC MEANS` to generate the desired summary statistics.

22. Explain the significance of visit windows in clinical trials and how to create them in SAS.

Answer: Visit windows are predefined time intervals used to assign observations to specific study visits when the actual visit dates may vary slightly from the scheduled dates. In clinical trials, visit windows ensure consistency in data analysis by grouping observations within a range of days around the scheduled visit date.

To create visit windows in SAS, you can define ranges of days relative to the baseline or scheduled visit and assign each observation to the appropriate window using conditional logic.

data visit_window;
   set adam_vitals;
   if (visit_date - baseline_date) between 0 and 7 then visit_window = "Week 1";
   else if (visit_date - baseline_date) between 8 and 14 then visit_window = "Week 2";
   else if (visit_date - baseline_date) > 14 then visit_window = "Week 3";
run;

23. What is the role of the AEDECOD and AEBODSYS variables in adverse event analysis?

Answer:

• AEDECOD (Adverse Event Dictionary-Derived Term): This variable contains the standardized medical term for each adverse event, typically coded using MedDRA. It is used to summarize and analyze adverse events by their preferred term.
• AEBODSYS (Adverse Event Body System): This variable categorizes adverse events by the body system affected (e.g., Gastrointestinal, Nervous System). It is used for summarizing adverse events by body system to identify patterns or treatment-related effects.

24. How do you generate Kaplan-Meier survival curves in SAS?

Answer: Kaplan-Meier survival curves are generated in SAS using PROC LIFETEST. These curves estimate the probability of survival over time and are often used in clinical trials to analyze time-to-event data (e.g., overall survival).

proc lifetest data=adam_survival plots=survival;
   time time_to_event*censor(0);
   strata treatment_group;
   survival out=km_curve;
run;

25. Explain how to derive the change from baseline in clinical trial data using SAS.

Answer: Change from baseline is a common analysis in clinical trials where you compare a subject's post-baseline measurement to their baseline value. To calculate the change from baseline in SAS, you typically subtract the baseline value from the current value.

data change_from_baseline;
   set adam_data;
   change = post_value - baseline_value;
run;

26. What is the purpose of the `PROC TTEST` procedure in clinical trials?

Answer: `PROC TTEST` is used to compare the means of two groups (e.g., treatment vs. placebo) to determine if there is a statistically significant difference. In clinical trials, it is often used to compare the effectiveness of different treatments on continuous outcomes such as blood pressure or cholesterol levels.

proc ttest data=adam_eff;
   class treatment_group;
   var change_from_baseline;
run;

27. How do you create demographic summaries in SAS for a clinical trial report?

Answer: To create a demographic summary for a clinical trial report, you need to summarize variables such as age, gender, race, and other baseline characteristics by treatment group. This can be done using PROC MEANS for continuous variables and PROC FREQ for categorical variables.

Example:

proc means data=adam_demog mean median stddev;
   class treatment_group;
   var age height weight;
run;

proc freq data=adam_demog;
   tables gender race / nocum;
   by treatment_group;
run;

28. What are Serious Adverse Events (SAEs), and how do you handle them in SAS?

Answer: Serious Adverse Events (SAEs) are adverse events that result in death, are life-threatening, require hospitalization, or cause significant disability. In SAS, SAEs are typically flagged using an indicator variable (e.g., SAEFLAG), and they are summarized separately from other adverse events in safety reports.

proc freq data=adam_ae;
   tables treatment_group*saeflag / nocum;
run;

29. How do you calculate time-to-event variables in clinical trials using SAS?

Answer: Time-to-event variables, such as time to death or time to disease progression, are calculated by taking the difference between the start date (e.g., randomization date) and the event date (or censoring date if the event did not occur).

data time_to_event;
   set adam_survival;
   time_to_event = event_date - randomization_date;
   if missing(event_date) then time_to_event = censor_date - randomization_date;
run;

30. How do you create a box plot in SAS for clinical data analysis?

Answer: Box plots are used in clinical data analysis to visually represent the distribution of a continuous variable. In SAS, you can create a box plot using PROC SGPLOT.

proc sgplot data=adam_data;
   vbox change_from_baseline / category=treatment_group;
run;

31. How do you handle lab data in clinical trials using SAS?

Answer: Handling lab data in clinical trials involves:

• Converting lab values to standard units if necessary.
• Flagging abnormal lab values (e.g., high or low values outside the normal range).
• Summarizing lab results by treatment group and over time.
• Creating listings for lab data abnormalities and changes from baseline.

32. How do you compare multiple treatments in a clinical trial using SAS?

Answer: Comparing multiple treatments in a clinical trial can be done using PROC ANOVA or PROC GLM for continuous outcomes, and PROC FREQ or PROC LOGISTIC for categorical outcomes. These procedures allow you to compare treatment groups and adjust for covariates if necessary.

proc glm data=adam_eff;
   class treatment_group;
   model change_from_baseline = treatment_group baseline_value;
   means treatment_group / hovtest=levene;
run;

33. What is an Interim Analysis, and how do you handle it in SAS?

Answer: Interim Analysis is a planned analysis conducted before the completion of a clinical trial to assess early efficacy or safety signals. It must be handled carefully to avoid introducing bias. In SAS, you can perform interim analysis using the same statistical procedures (e.g., PROC TTEST, PROC FREQ) but should clearly document that it is an interim analysis and ensure proper data handling to maintain study integrity.

34. How do you generate summary statistics by treatment group in SAS?

Answer: You can generate summary statistics by treatment group using PROC MEANS or PROC UNIVARIATE for continuous variables, and PROC FREQ for categorical variables.

Example using PROC MEANS:

proc means data=adam_data mean std min max;
   class treatment_group;
   var change_from_baseline;
run;

Example using PROC FREQ:

proc freq data=adam_data;
   tables treatment_group*response / chisq;
run;

35. How do you perform data cleaning in clinical trial datasets using SAS?

Answer: Data cleaning in clinical trial datasets involves identifying and correcting errors, inconsistencies, or missing values in the data. Common data cleaning tasks include:

• Checking for and handling missing values using techniques such as imputation or exclusion.
• Verifying that values are within acceptable ranges and flagging outliers.
• Standardizing variable names, labels, and formats across datasets.
• Ensuring consistency between related datasets (e.g., ensuring subject IDs match across datasets).
• Documenting all cleaning steps for transparency and reproducibility.

36. What is a protocol deviation, and how do you handle it in SAS?

Answer: A protocol deviation is any change, divergence, or departure from the study protocol that is not approved by the Institutional Review Board (IRB). Handling protocol deviations in SAS involves:

• Identifying and flagging deviations in the data.
• Summarizing the deviations by type, frequency, and treatment group.
• Documenting how deviations were handled in the analysis (e.g., including or excluding affected data).

data protocol_deviation;
   set sdtm_data;
   if deviation_flag = 1 then output;
run;

proc freq data=protocol_deviation;
   tables deviation_type / nocum;
   by treatment_group;
run;

37. Explain the importance of randomization in clinical trials and how it is implemented in SAS.

Answer: Randomization is crucial in clinical trials as it reduces bias by randomly assigning subjects to different treatment groups, ensuring that the groups are comparable. In SAS, randomization can be implemented using the RANUNI function or by generating a random number to assign subjects to treatment groups.

data randomized;
   set sdtm_data;
   retain seed 12345;
   random_number = ranuni(seed);
   if random_number <= 0.5 then treatment_group = 'A';
   else treatment_group = 'B';
run;

38. What is the purpose of PROC PHREG in clinical trials?

Answer: PROC PHREG is used for survival analysis in clinical trials, particularly when dealing with time-to-event data and the proportional hazards model (Cox regression). It allows for the inclusion of covariates in the model and assesses the effect of treatment on survival times.

proc phreg data=adam_survival;
   class treatment_group;
   model time_to_event*censor(0) = treatment_group baseline_covariate;
run;

39. How do you handle visit windows for longitudinal data in SAS?

Answer: Handling visit windows for longitudinal data involves assigning each observation to a predefined visit window based on the actual visit date. This is done to account for variations in visit timing and to standardize the data for analysis.

data visit_window;
   set adam_vitals;
   if (visit_date - baseline_date) <= 7 then visit_window = "Week 1";
   else if (visit_date - baseline_date) <= 14 then visit_window = "Week 2";
   else visit_window = "Week 3";
run;

40. What are the different types of censoring in survival analysis, and how do you implement them in SAS?

Answer: Censoring in survival analysis occurs when the outcome of interest (e.g., death or disease progression) is not observed within the study period. There are three main types of censoring:

• Right Censoring: The event has not occurred by the end of the study or the subject is lost to follow-up.
• Left Censoring: The event occurs before the subject enters the study.
• Interval Censoring: The event occurs within a known time interval, but the exact time is unknown.

In SAS, censoring is typically handled by defining a censoring variable in survival analysis procedures like PROC LIFETEST or PROC PHREG.

proc lifetest data=adam_survival;
   time time_to_event*censor(0);
   strata treatment_group;
run;

41. How do you generate adverse event frequency tables in SAS?

Answer: Adverse event (AE) frequency tables summarize the occurrence of AEs by treatment group, often showing the number and percentage of subjects experiencing each AE. These tables can be generated using PROC FREQ or PROC REPORT in SAS.

proc freq data=adam_ae;
   tables treatment_group*ae_decod / norow nocol nopercent;
run;

42. Explain the difference between PROC GLM and PROC MIXED in the context of clinical trials.

Answer:

• PROC GLM: Used for analyzing data from linear models with fixed effects. It is suitable for analyzing data from clinical trials where the model does not include random effects.
• PROC MIXED: Used for analyzing data from mixed models that include both fixed and random effects. It is often used in clinical trials with repeated measures or hierarchical data.

43. How do you prepare data for a Clinical Study Report (CSR) in SAS?

Answer: Preparing data for a Clinical Study Report (CSR) involves several steps:

• Ensuring that all datasets are complete, accurate, and compliant with CDISC standards.
• Creating tables, listings, and figures (TLFs) that summarize the study data.
• Generating analysis datasets (ADaM) that support the primary and secondary endpoints of the study.
• Using ODS to produce formatted outputs suitable for inclusion in the CSR.
• Documenting all steps taken to prepare the data and ensuring traceability from raw data to final outputs.

44. What is the role of PROC UNIVARIATE in clinical trials?

Answer: PROC UNIVARIATE is used to provide detailed descriptive statistics and distributional information for continuous variables. In clinical trials, it is often used to assess the normality of variables, identify outliers, and summarize baseline characteristics.

proc univariate data=adam_data;
   var change_from_baseline;
   histogram change_from_baseline / normal;
   qqplot change_from_baseline;
run;

45. How do you ensure compliance with CDISC standards in SAS?

Answer: Ensuring compliance with CDISC standards involves the following:

• Using CDISC-compliant templates and metadata to structure SDTM and ADaM datasets.
• Validating datasets against CDISC rules using tools like Pinnacle 21 or SAS Clinical Standards Toolkit.
• Generating `DEFINE.XML` files that accurately document the structure and content of the datasets.
• Ensuring traceability and consistency between SDTM, ADaM, and analysis outputs.

46. What is a Data Monitoring Committee (DMC), and how is SAS used in DMC reports?

Answer: A Data Monitoring Committee (DMC) is an independent group of experts that monitors the safety and efficacy of a clinical trial while it is ongoing. SAS is used to generate DMC reports that summarize safety data, efficacy endpoints, and interim analyses to inform the committee's decisions.

proc report data=adam_safety nowd;
   column subject_id treatment_group adverse_event severity;
   define subject_id / group 'Subject ID';
   define treatment_group / group 'Treatment Group';
   define adverse_event / 'Adverse Event';
   define severity / 'Severity';
run;

47. How do you use PROC SGPLOT to visualize clinical trial data?

Answer: PROC SGPLOT is a powerful tool in SAS for creating a wide range of visualizations, including scatter plots, bar charts, and box plots. In clinical trials, it is often used to visualize treatment effects, adverse events, and other key data points.

proc sgplot data=adam_eff;
   scatter x=visit y=change_from_baseline / group=treatment_group;
   series x=visit y=change_from_baseline / group=treatment_group;
   xaxis label='Visit';
   yaxis label='Change from Baseline';
run;

48. What are the common challenges in clinical SAS programming, and how do you address them?

Answer: Common challenges in clinical SAS programming include:

• Data Quality: Ensuring the accuracy and completeness of clinical trial data. Addressed by thorough data validation and cleaning processes.
• Compliance: Adhering to regulatory standards such as CDISC. Addressed by using standard templates and validation tools like Pinnacle 21.
• Complex Study Designs: Handling complex study designs such as crossover or adaptive trials. Addressed by careful planning and the use of appropriate statistical methods and SAS procedures.
• Traceability: Maintaining clear documentation and traceability from raw data to final outputs. Addressed by meticulous documentation and the use of `DEFINE.XML` files.

49. How do you manage and document changes to SAS programs in a clinical trial setting?

Answer: Managing and documenting changes to SAS programs is critical for maintaining the integrity and reproducibility of clinical trial results. Key practices include:

• Version Control: Using version control systems (e.g., Git) to track changes to SAS programs over time.
• Change Logs: Maintaining detailed change logs that document the reason for each change, who made it, and when.
• Peer Review: Conducting peer reviews of changes to ensure accuracy and adherence to best practices.
• Documentation: Updating program documentation to reflect changes and ensure that the rationale and impact of each change are clearly understood.

50. What is the importance of sample size calculation in clinical trials, and how do you perform it in SAS?

Answer: Sample size calculation is crucial in clinical trials to ensure that the study is adequately powered to detect a treatment effect if one exists. It involves determining the number of subjects needed to achieve a specified power level given the expected effect size and significance level.

proc power;
   twosamplemeans test=diff
   mean1=70 mean2=75
   stddev=10
   ntotal=.
   power=0.8
   alpha=0.05;
run;